Customer reviews

1. 

   April SC

   maio 23, 2025

   I have some genetic issues that impair my detox pathways, MTHFR heterozygous, MTRR heterozygous and VDR homozygous. Additionally, I have had some environmental illnesses/symptoms (metals, lyme/coinfections and mold-with the mold gene).

   I take A.LOT of supplements, and NAC is BY FAR the backbone of my treatment/wellness. I couldn’t/and WILL NEVER be without it. I have taken a lot of different forms-straight glutathione, liposomal, straight NAC…and lots of different brands. Jarrow Sustain is EASILY my favorite. Right now I am taking 2-2 capsule doses in the morning on an empty stomach (each 2 capsule dose separated by an hr since 4 all at once gives me more energy than I like) and then do the same in the late afternoon. EMPTY STOMACH IS CRUCIAL for it to work best. Yes, I take at least 8 a day currently.

   I have been detoxing/treating for the past 18 months and under the direction of my functional medicine doctor, I have been instructed to take 2000mg of NAC 2x/day. I have read elsewhere (Stephen Buhner) that I could push the dose up to 4000mg 2x a day if deemed necessary with no ill effects. FWIW, most studies on efficacy used 4000-5000mg daily and found that dose to be optimal for noticeable improvements. All that to say, if you aren’t noticing improvements, you may need a higher dose, but listen to your body. It took me about 6 months to slowly get up to this dose without feeling common side effects like anxiety/restlessness. I started with a half a pill daily (even though it negated the sustained factor) and S-L-O-W-L-Y worked my way up. Take your time and titrate. We don’t have to get better tomorrow…we just have to get better, period.

   If your detox pathways are closed, you will feel side effects. If so, don’t give up on NAC. Do your research and start by opening up your pathways and supporting your methylation cycle, then try it again. I wasn’t successful with NAC the first time for this reason. I had crazy anxiety with just a few hundred mg. But, as I’ve detoxed and supported my body, I easily tolerate this dose and feel so much better.

   I am a 5’5, female and 115lbs FWIW. Hope this helps someone 🙂

2. 

   Smoon

   junho 8, 2025

   I made sure to take this for a few months before posting a review to be sure that it was the supplement that was helping me. I’ve had weird autoimmune symptoms for years now that reached their all time worst this year. I was having chronic hives, bad sleep, sweats, joint pain, bloating, eye floaters, itching, tingling ,HORRIBLE heart palpitations etc. my doctors couldn’t figure it out. My thyroid was a little off but nothing major and I had estrogen dominance but not severely. They tried to treat those issues and my symptoms only worsened. I found someone who was having similar symptoms to mine and she said her doctor thought she had something called MCAS – mast cell activation syndrome. NAC is recommended along with Quercetin to help treat MCAS. The first week of taking NAC, I only had to take my heart medicine (atenolol) once that week when I usually take it 1-2x a day. I didn’t want to get excited only to get let down so I continued taking it and monitoring my condition. It has now been three months and I have not taken a single heart medicine since. My palpitations are now few and far between. I used to wake up every night sweating with my heart racing through the roof and that hasn’t happened since supplementing with NAC. My hives are not as chronic and my sleep quality has improved and I have more energy. I am so thankful I found out about this supplement and I hope my experience can help anyone going through something similar.

3. 

   Drew Trotman

   junho 30, 2025

   A friend of mine and I used to joke about how it’s like breathing in yogurt here in the south with the heat, humidity and allergens. We were fellow asthma sufferers. I had been on an inhaled corticosteroid (Asmanex) for five years, due to adult onset asthma. I’m grateful for Asmanex because it helped me to breathe and kept my lungs from being damaged. I tried several times to go off of it because you never know what side effects await you down the road. But to no avail. After a few days I would go back on it because I like breathing. My friend texted me one day and told me she wasn’t breathing yogurt anymore because of NAC. So I decided to try it. I picked up the Jarrow NAC sustained release and started out with three a day. Then two, Then one. Now all I do is take one each morning as soon as I wake up and I have no problems breathing and I am off of Asmanex successfully. This supplement has been endorsed by both the traditional and the alternative medical communities. NAC is what they give you if you go into the ER with acetaminophen poisoning. Evidently it binds it and takes it out of your system. It is also supposed to boost your immune system and there are a host of other things that it does for you. For me, just being able to breathe without drugs is a beautiful thing. And btw, I can breathe better using NAC than I could on the inhaled corticosteroid. Even on Asmanex, I couldn’t be in a room with cooking or burning grease. Now it doesn’t bother me at all. And I never need a rescue inhaler. Humidity hasn’t bothered me either. For some reason, Jarrow’s sustained release works better for me than straight NAC. Don’t know why, but I don’t argue with results. I’m surprised that more pulmonologists and allergists don’t know about this. I guess information takes time to circulate. Try NAC. It’s probably the most significant supplement I have ever taken. There are no contraindications with medication (with the exception of Nitroglycerin), and the only side effect known is possible stomach upset. I have a pretty sensitive stomach and it hasn’t affected me at all. There’s a ton of research on NAC. In a major study, it even slowed the progression and severity of COPD in older adults. If you have any doubts, just research it online. It’s very safe, and the results can be incredible. At least they were for me. You’ll never know until you try it. It could change your life too. Note: “D. Corbo” (see comment on my review) offered some helpful info saying that it should not be taken if you are taking Nitroglycerin and he has also read recommendations to supplement NAC with Vit C (3000 mg Vit C for every 1000 mg) and perhaps consider supplementing a bit of minerals (zinc, copper, trace minerals). As with all health products whether they are drugs, supplements, or herbs, do your own research on legit medical or scientific websites before taking something. This review is meant to encourage you to research this as an option for treating issues concerning breathing.